Phenotypes Associated with This Genotype

Genotype
MGI:3044706

• Allelic Composition: Wfs1^tm1Yoka/Wfs1^tm1Yoka
• Genetic Background: B6.Cg-Wfs1^tm1Yoka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:90420 )

• the number of beta cells decreases with age in homozygous mice probably as a result of increased beta cell susceptibility to apoptosis

• this effect is more prominent on a [(129/Sv x C57BL/6) x C57BL/6]F2 background than on a C57BL/6 background

abnormal pancreas secretion ( J:90420 )

• insulin content in islets is decreased by 16% compared to wild-type islets

• glucose stimulated insulin secretion normalized to insulin content is decreased 23% compared to wild-type mice

increased glucagon secretion ( J:90420 )

• glucagon positive cells and pancreatic glucagon content are increased in homozygous mice at 36 weeks of age

homeostasis/metabolism

increased glucagon secretion ( J:90420 )

• glucagon positive cells and pancreatic glucagon content are increased in homozygous mice at 36 weeks of age

decreased circulating insulin level ( J:90420 )

• plasma insulin concentrations are reduced by 50% in homozygous mice at 36 weeks of age but no difference in plasma insulin concentrations are seen at 24 weeks of age

impaired glucose tolerance ( J:90420 )

• blood glucose levels are significantly higher 15 and 30 minutes into an oral glucose tolerance test

• at 17 weeks of age increase in plasma insulin concentrations in response to glucose load are decreased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Wolfram syndrome 1		DOID:0110629	OMIM:222300	J:90420