Analysis Tools
behavior/neurological
| N |
• male and female homozygotes showed normal baseline feeding and body weight gain
• male homozygotes displayed normal locomotor activity in the elevated plus-maze test, and in a novel environment
• female homozygotes showed normal baseline anxiety levels, stress-induced anxiety, and locomotor activity relative to wild-type
• baseline anxiety of female wild-type and homozygous mice did not change with regard to estrous cycle phase
• female homozygotes showed normal behavior in the dark-light emergence task, open-field and acute locomotor activity test
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• in the elevated plus-maze, homozygous males appeared to be more anxious than wild-type males
• in the open-field, homozygotes were explorative and did not differ from wild-type in traveled distance and time spent in the peripheral zones; however, homozygotes showed increased center region activity
• a single 5-min exposure to the elevated plus-maze resulted in a sustained elevation of phosphorylated Creb and widespread Fos production
• the levels of pCreb were lower in specific brain regions of male, but not female, homozygotes compared with wild-type controls: these regions included the cingulate cortex, the bed nucleus of the stria terminalis, the ventromedial hypothalamic nucleus and the basolateral amygdala
• all genotypes showed a similar level and distribution of Fos protein after exposure to the pus-maze regardless of gender
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cardiovascular system
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• homozygotes of both genders exhibited increased edema formation in response to thermal injury relative to wild-type
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hearing/vestibular/ear
| N |
• no auditory or orientational deficits
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homeostasis/metabolism
| N |
• homozygotes displayed a normal activation of the HPA axis in response to 10 minutes of physical restraint stress
• the increased POMC1 (ACTH) and corticosterone levels produced by male or female homozygotes did not differ from the values obtained for matched wild-type controls
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vision/eye
| N |
• no visual deficits
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