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Phenotypes Associated with This Genotype
Genotype
MGI:3044890
hm1
Allelic
Composition		 Spred2tm1Taga/Spred2tm1Taga
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spred2tm1Taga mutation (1 available); any Spred2 mutation (222 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:90463 )
• E11.5 aortic cells form significantly more macrophage and granulocyte colonies in culture
• culture of the aorta-gonad-mesonephros from homozygous embryos produces 3 fold more hematopoietic cells compared to wild-type
• about 2-fold more hematopoietic cell colonies are produced in bone marrow cell cultures from homozygous mice
increased megakaryocyte cell number ( J:90463 )
• increased numbers of megakaryocytes are seen in the spleens of homozygous mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory