Phenotypes Associated with This Genotype

Genotype
MGI:3045183

• Allelic Composition: Psen1^tm1Jzt/Psen1^tm1Jzt; Tg(Camk2a-cre)T29-1Stl/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:73252 )

• exposure to environmental enrichment following contextual fear conditioning results in a significant increase in freezing responses during retention tests

cellular

decreased cell proliferation ( J:73252 )

• environmental enrichment induces significantly less neurogenesis in the dentate gyrus of the brain in mutants compared to wild-type controls

nervous system

abnormal dentate gyrus morphology ( J:73252 )

• following environmental enrichment the number of newborn neurons in the subgranular zone and molecular layer of the dentate gyrus are 39% and 48% less respectively compared to wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:73252