Phenotypes Associated with This Genotype

Genotype
MGI:3045711

• Allelic Composition: Htr1a^tm1Rhn/Htr1a^tm1Rhn
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavioral despair ( J:51280 )

• in the forced swim test, homozygotes are significantly more active than wild-type, particularly during the last 10 min of the test

• homozygotes appear to display less behavioral despair than wild-type littermates; whereas wild-type mice become progressively more immobile, homozygous mutants maintain the same level of activity throughout the swim test

increased anxiety-related response ( J:51280 )

• in the open field, homozygotes exhibit decreased exploratory activity and increased anxious-like behavior relative to wild-type

• in the elevated plus maze, homozygotes display significantly more anxiety-like behaviors with no significant changes in activity

• homozygous null males appear to be affected more than females, particularly in some measures of anxiety

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
anxiety disorder		DOID:2030	OMIM:607834	J:51280