Phenotypes Associated with This Genotype

Genotype
MGI:3046320

hm2

• Allelic Composition: Myo15a^sh2/Myo15a^sh2
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal organ of Corti morphology ( J:13046 )

abnormal cochlear hair cell morphology ( J:6873 , J:13046 )

• by 2.5 months of age type 1 hair cells of the crista ampullaris and utricular macula contain rod-shaped inclusions comprising actin filaments (J:6873)

• degeneration is evident in 2 week old mice (J:13046)

organ of Corti degeneration ( J:13046 )

• occurs during the second week

abnormal stria vascularis morphology ( J:13046 )

• evident in 3 week old mutant mice

abnormal tectorial membrane morphology ( J:13046 )

• the membrane is slow to thin to expected dimensions

abnormal utricular macula morphology ( J:13046 )

deafness ( J:13046 )

• due to cochlear degeneration

behavior/neurological

head shaking ( J:13046 )

circling ( J:13046 )

• mutant mice show a tendency to run in circles

nervous system

abnormal cochlear hair cell morphology ( J:6873 , J:13046 )

• by 2.5 months of age type 1 hair cells of the crista ampullaris and utricular macula contain rod-shaped inclusions comprising actin filaments (J:6873)

• degeneration is evident in 2 week old mice (J:13046)

abnormal cochlear ganglion morphology ( J:13046 )

cochlear ganglion degeneration ( J:13046 )

• degeneration is progressive from the time mutants are two weeks old