Phenotypes Associated with This Genotype

Genotype
MGI:3046808

• Allelic Composition: Cdkn1a^tm2(HBx)Xya/Cdkn1a^tm2(HBx)Xya
• Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma (HCC) observed in 63.6% of male mice and in 42.9% of female mice after 18 months of age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• HCC compressing adjacent normal hepatocytes observed after 18 months of age and typically associated with fatty liver and inflammation

liver/biliary system

hepatic steatosis ( J:88078 )

• observed in some mice

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma (HCC) observed in 63.6% of male mice and in 42.9% of female mice after 18 months of age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• HCC compressing adjacent normal hepatocytes observed after 18 months of age and typically associated with fatty liver and inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:88078