Phenotypes Associated with This Genotype

Genotype
MGI:3046865

cx7

• Allelic Composition: Rel^tm1Grd/Rel^tm1Grd; Rela^tm1Bal/Rela^tm1Bal; Tnf^tm1Ljo/Tnf^tm1Ljo
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:91366 )

• triple homozygous pups die within 12 hours of birth

cellular

abnormal cell cycle ( J:91366 )

• transit-amplifying epidermal cells display a delay in G₁/S phase progression

decreased cell proliferation ( J:91366 )

• transit-amplifying epidermal cells display reduced proliferation

embryo

decreased embryo size ( J:91366 )

• triple homozygous embryos are about 30% smaller compared to littermate controls

growth/size/body

decreased embryo size ( J:91366 )

• triple homozygous embryos are about 30% smaller compared to littermate controls

integument

abnormal hair follicle placode formation ( J:91366 )

• about a 24 hour delay in hair placode formation is seen compared to control littermates

underdeveloped hair follicles ( J:91366 )

• at E18 the hair follicles that are present are only rudimentary buds lacking hair shafts

decreased hair follicle number ( J:91366 )

• at E18, 70% fewer hair follicles are present compared to control littermates

abnormal epidermal layer morphology ( J:91366 )

abnormal epidermis stratum basale morphology ( J:91366 )

• the cells in the basal cell layer are organized differently and the basal cell profile area is reduced by about 33%

abnormal keratinocyte morphology ( J:91366 )

• the number of differentiating keratinocytes is reduced

thin epidermis ( J:91366 )

• the epidermis is significantly thinner