Phenotypes Associated with This Genotype

Genotype
MGI:3047402

• Allelic Composition: Gnai2^tm1Lbi/Gnai2^tm1Lbi
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:24434 )

• the mean age of spontaneous death was 21 weeks

• 75% had died by 36 weeks of age

postnatal lethality, incomplete penetrance ( J:24434 )

• death sometime between E14 and 4 weeks of age

neoplasm

increased intestinal adenocarcinoma incidence ( J:24434 )

• tumors were largely confined to the large intestine with none being observed in the small intestine

digestive/alimentary system

abnormal colon morphology ( J:24434 )

• colons were irregularly dilated and had focally thickened and inflamed walls

• the small intestines were unaffected

increased intestinal adenocarcinoma incidence ( J:24434 )

• tumors were largely confined to the large intestine with none being observed in the small intestine

colitis ( J:24434 )

• exhibited by all mice by 13 weeks of age

• chronic active inflammation with the distal colon being most affected

growth/size/body

decreased body weight ( J:24434 )

• weight decreased by 20% to 30% prior to death

postnatal growth retardation ( J:24434 )

immune system

colitis ( J:24434 )

• exhibited by all mice by 13 weeks of age

• chronic active inflammation with the distal colon being most affected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease 12		DOID:0110887	OMIM:612241	J:24434