Analysis Tools
mortality/aging
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• mean age of death is 20 weeks
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• death sometime between E14 and 4 weeks of age
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neoplasm
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• tumors were largely confined to the large intestine with none being observed in the small intestine
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digestive/alimentary system
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• with heavy chronic infiltration of lymphocytes and active plasma cells
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• loss of mucus from goblet cells of crypts, atypia and loss of crypts
• glands regenerate with typical characteristics of adenocarcinomas as well as penetrating the submucosa and extending to the smooth muscle layer
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• colons were irregularly dilated and had focally thickened and inflamed walls
(J:24434)
• the small intestines were unaffected
(J:24434)
• at necropsy walls are focally thickened
(J:30507)
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• tumors were largely confined to the large intestine with none being observed in the small intestine
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• seen in 21 of 26 mice
• inflammation is restricted to the rectum and colon
• diffuse but not patchy pattern of inflammation resembles ulcerative colitis
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• exhibited by all mice by 13 weeks of age
• chronic active inflammation with the distal colon being most affected
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• perforation and peritonitis are present at necropsy
• serosal discoloration and increased vascularity are also observed at necropsy
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immune system
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• at 8 weeks, the spleen contain a significantly larger number of granulocytes compared to wild-type mice
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• 3-fold increase in CD3+ cells
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• 2- to 4-fold increase in single positive thymocytes
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• proliferative response to phorbol myristate acetate (PMA), staphylococcal enterotoxin A (SEA) and BABL/c(H-2s) is increased by 3- to 5-fold
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• myeloperoxidase (MPO) levels from neutrophils are significantly lower than in wild-type at the site of infection
• however, neutrophil function is normal and serum taken from immunized mice is able to confer immunity to nae wild-type mice
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• twice as high as in wild-type mice
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• twice as high as in wild-type mice
• markedly elevated in the large intestine but only modestly so in the small intestine
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• IFN-gamma levels in non-immunized and immunized mice are increased compared to immunized wild-type mice
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• IL-4 levels are significantly higher after immunization against S. stercorallis
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• IL-5 levels are significantly higher after immunization against S. stercorallis
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• stimulated spleen and lymph node T cells and thymocytes produce several fold more INF-gamma
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• stimulated spleen and lymph node T cells and thymocytes produce several fold more IL-2
• however, IL-4 production from stimulated spleen and lymph node T cells and thymocytes is only modestly enhanced if at all
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• stimulated spleen and lymph node T cells and thymocytes produce several fold more TNF
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• seen in 21 of 26 mice
• inflammation is restricted to the rectum and colon
• diffuse but not patchy pattern of inflammation resembles ulcerative colitis
|
|
• exhibited by all mice by 13 weeks of age
• chronic active inflammation with the distal colon being most affected
|
|
• serosal discoloration and increased vascularity are also observed at necropsy
• perforation and peritonitis are present at necropsy
|
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• following immunization and exposure to S. stercorallis, mice have decreased larval killing of 37% compared to 91% in wild-type mice
• IL-4 and IL-5 levels are significantly higher after immunization against S. stercorallis
• fewer neutrophils, eosinophils, macrophages, and lymphocytes are recruited into the site of infection
• myeloperoxidase (MPO) levels from neutrophils are significantly lower than in wild-type at the site of infection
• however, serum taken from immunized mice is able to confer immunity to nae wild-type mice
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growth/size/body
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• at 6 weeks, mice gain weight slower
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weight loss
(
J:30507
)
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• at 6 weeks, mice gain weight slower
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homeostasis/metabolism
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• IFN-gamma levels in non-immunized and immunized mice are increased compared to immunized wild-type mice
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• IL-4 levels are significantly higher after immunization against S. stercorallis
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• IL-5 levels are significantly higher after immunization against S. stercorallis
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• response to prostoglandin E and nicotinic acid is blunted about 50%
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• inhibition of adenylyl cyclase in response to phenylisopropyl adenosine or carbachol is blunted about 50%
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• proliferative response to phorbol myristate acetate (PMA), staphylococcal enterotoxin A (SEA) and BABL/c(H-2s) is increased by 3- to 5-fold
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hematopoietic system
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• proliferative response to phorbol myristate acetate (PMA), staphylococcal enterotoxin A (SEA) and BABL/c(H-2s) is increased by 3- to 5-fold
|
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• at 8 weeks, the spleen contain a significantly larger number of granulocytes compared to wild-type mice
|
|
• 3-fold increase in CD3+ cells
|
|
• 2- to 4-fold increase in single positive thymocytes
|
|
• myeloperoxidase (MPO) levels from neutrophils are significantly lower than in wild-type at the site of infection
• however, neutrophil function is normal and serum taken from immunized mice is able to confer immunity to nae wild-type mice
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• twice as high as in wild-type mice
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• twice as high as in wild-type mice
• markedly elevated in the large intestine but only modestly so in the small intestine
|
endocrine/exocrine glands
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• loss of mucus from goblet cells of crypts, atypia and loss of crypts
• glands regenerate with typical characteristics of adenocarcinomas as well as penetrating the submucosa and extending to the smooth muscle layer
|
cellular
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• proliferative response to phorbol myristate acetate (PMA), staphylococcal enterotoxin A (SEA) and BABL/c(H-2s) is increased by 3- to 5-fold
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| inflammatory bowel disease 12 | DOID:0110887 |
OMIM:612241 |
J:24434 , J:30507 | |
