Phenotypes Associated with This Genotype

Genotype
MGI:3047407

• Allelic Composition: Gnai2^tm1Lbi/Gnai2^tm1Lbi
• Genetic Background: 129-Gnai2^tm1Lbi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:91100 )

N • Background Sensitivity: mice on a 129X1/SvJBom genetic background do not develop colitis

abnormal cytokine secretion ( J:91100 )

• production of pro-inflammatory cytokines, TNF and IL-1beta, and the Th1 promoting cytokine IL-12p40, are increased in response to formalin-killed Saphylococcus aureus

• Background Sensitivity: superantigenic stimulation with toxic shock syndrome toxin-1 of splenocytes results in increased production of TNF and IL-1beta, but not of IL-12p40, as is seen on the mixed 129S7/SvEvBrd and C57BL/6 background

increased interleukin-1 beta secretion ( J:91100 )

• in response to formalin-killed Saphylococcus aureus and toxic shock syndrome toxin-1

increased tumor necrosis factor secretion ( J:91100 )

• in response to formalin-killed Saphylococcus aureus and toxic shock syndrome toxin-1

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	inflammatory bowel disease 12	DOID:0110887	OMIM:612241	J:91100