Phenotypes Associated with This Genotype

Genotype
MGI:3050098

cx3

• Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol; Lum^tm1Chak/Lum⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

decreased tendon stiffness ( J:83544 )

• compound mutant mice show a 45% reduction in tendon stiffness and a 29% reduction in tensile modulus relative to wild-type

• the severity of stiffness reduction increases with the loss of each functional lumican allele in a lumican dose-dependent fashion

skeleton

decreased tendon stiffness ( J:83544 )

• compound mutant mice show a 45% reduction in tendon stiffness and a 29% reduction in tensile modulus relative to wild-type

• the severity of stiffness reduction increases with the loss of each functional lumican allele in a lumican dose-dependent fashion