Phenotypes Associated with This Genotype

Genotype
MGI:3050555

• Allelic Composition: Prkn^tm1Tmd/Prkn^tm1Tmd
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decrease in tyrosine hydroxylase (TH) containing neurons in the locus coeruleus (LC) of Prkn^tm1Tmd/Prkn^tm1Tmd mice

behavior/neurological

decreased startle reflex ( J:91487 )

• the acoustic startle reflex is significantly decreased

nervous system

abnormal locus ceruleus morphology ( J:91487 )

• a reduction in dopamine neuron number is seen in the locus coeruleus by 2 months of age

homeostasis/metabolism

decreased noradrenaline level ( J:91487 )

• norepinephrine levels are reduced in the locus coeruleus, olfactory bulb, and spinal cord but not in the cerebral cortex, brainstem, prefrontal cortex, hippocampus, diencephalon, and cerebellum of homozygous mutants compared to wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 2		DOID:0060368	OMIM:600116	J:91487