Phenotypes Associated with This Genotype

Genotype
MGI:3050895

• Allelic Composition: Msx2^tm1Rilm/Msx2⁺; Twist1^tm1Bhr/Twist1⁺
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

frontal bone foramen ( J:87044 )

• in double heterozygotes, the frontal foramen phenotype is 3x more severe than in either single heterozygote

limbs/digits/tail

polydactyly ( J:87044 )

• in double heterozygotes, the incidence of digit duplication is identical to that observed in Twist1^tm1Bhr heterozygotes (34%)

skeleton

frontal bone foramen ( J:87044 )

• in double heterozygotes, the frontal foramen phenotype is 3x more severe than in either single heterozygote

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Saethre-Chotzen syndrome		DOID:14768	OMIM:101400 OMIM:180750	J:87044