Phenotypes Associated with This Genotype

Genotype
MGI:3051589

• Allelic Composition: Ghrh^tm1Salv/Ghrh^tm1Salv
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

pituitary gland hypoplasia ( J:91828 )

growth/size/body

decreased body weight ( J:91828 )

• by 8 weeks of age body weight was 55-60% of controls

decreased body length ( J:91828 )

• body length about 3/4 that of controls

postnatal growth retardation ( J:91828 )

• homozygotes from heterozygous mothers showed slower growth rates

• slightly smaller than controls at 2 weeks of age

• significantly smaller than controls at 3 weeks of age

• only 55-60% of control body weight by 8 weeks of age

liver/biliary system

abnormal liver physiology ( J:91828 )

• IGF-I production reduced

reproductive system

decreased litter size ( J:91828 )

• females produced smaller than normal litters

• 8.5% mortality of pups in first 24 hours

• normal maternal behavior in spite of failure to thrive observed in mice born from primiparous mothers

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:91828 )

• serum IGF-I levels reduced

decreased growth hormone level ( J:91828 )

• pituitary growth hormone levels about 1/5 normal

nervous system

pituitary gland hypoplasia ( J:91828 )

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:177054 )

♀

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
isolated growth hormone deficiency type IA		DOID:0060873	OMIM:262400	J:91828