Phenotypes Associated with This Genotype

Genotype
MGI:3052308

• Allelic Composition: Hr^rhsl/Hr^rhsl
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:98859 )

• death usually at 6- 10 months of age

behavior/neurological

abnormal nursing ( J:98859 )

♀ • females do not nurse their young well

immune system

thymus atrophy ( J:98859 )

• accelerated atrophy with age

hematopoietic system

thymus atrophy ( J:98859 )

• accelerated atrophy with age

integument

alopecia ( J:98859 )

• coat is normal up to 12 days when hair loss starts to occur, first around the eyes and progressing in the direction of the tail, with total loss within 2 weeks

long toenails ( J:98859 )

• excessively long and curved, especially the toes of the hind limbs

abnormal hair follicle morphology ( J:98859 )

• extensive hyperkeratosis in hair follicles

abnormal vibrissa morphology ( J:92362 )

• repeatedly shed and regrown becoming more abnormal with age

abnormal skin morphology ( J:98859 )

abnormal keratinocyte differentiation ( J:98859 )

• very extensive hyperkeratosis in hair follicles

abnormal dermal layer morphology ( J:98859 )

• formation of hypertrophic and excessively large utriculi that were filled with masses of cornified material in the dermis

dermal cyst ( J:98859 )

• extensive development of dermal cysts with advancing age leading to thickening of the skin

hyperkeratosis ( J:98859 )

• follicular and epidermal hyperkeratosis

flaky skin ( J:98859 )

• aging mice have a waxy deposition on the skin that peels off in large flakes

loose skin ( J:98859 )

• skin becomes loose, forming rhinoceros-like folds

wrinkled skin ( J:98859 )

thick skin ( J:98859 )

• skin becomes thick and wrinkled with age

cellular

abnormal keratinocyte differentiation ( J:98859 )

• very extensive hyperkeratosis in hair follicles

endocrine/exocrine glands

thymus atrophy ( J:98859 )

• accelerated atrophy with age

growth/size/body

dermal cyst ( J:98859 )

• extensive development of dermal cysts with advancing age leading to thickening of the skin

limbs/digits/tail

long toenails ( J:98859 )

• excessively long and curved, especially the toes of the hind limbs

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alopecia universalis		DOID:0050634	OMIM:203655	J:98859
atrichia with papular lesions		DOID:0060689	OMIM:209500	J:98859