Phenotypes Associated with This Genotype

Genotype
MGI:3052466

• Allelic Composition: Ciita^tm2Wrth/Ciita^tm2Wrth
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:92170 )

• reduced numbers of CD4+ T cells

• results in lymphopenia

abnormal immunoglobulin level ( J:92170 )

• no antibody response to T-cell dependent antigens

immune system

decreased CD4-positive, alpha-beta T cell number ( J:92170 )

• reduced numbers of CD4+ T cells

• results in lymphopenia

abnormal immunoglobulin level ( J:92170 )

• no antibody response to T-cell dependent antigens

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
MHC class II deficiency		DOID:5812	OMIM:209920	J:92170