Analysis Tools
hematopoietic system
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• increase in circulating neutrophils during induced nephritis
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• defective attachment to insoluble immune complexes
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• in response to induced glomerulonephritis, 75-83% reduction in glomerular neutrophil accumulation
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immune system
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• increase in circulating neutrophils during induced nephritis
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• defective attachment to insoluble immune complexes
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• in response to induced glomerulonephritis, 75-83% reduction in glomerular neutrophil accumulation
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• considerably reduced when induced with myelin oligodendrocyte glycoprotein
• more frequent disease remission
• lower incidence of anaphylaxis from a second dose of myelin oligodendrocyte glycoprotein
• fewer inflammatory foci in the central nervous system
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• less cell influx into the synovial layer and joint cavity 3 days after arthritis induction using immune complexes
• knee joint swelling is also reduced relative controls at both 1 and 3 days after induction
• less proteoglycan loss relative to controls at 1 and 3 days after induction
• chondrocyte death 3X the level in controls at 3 days after induction but normal at 1 day on the femoral surface
• chondrocyte cell death is unaffected on the patellar surface
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skeleton
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• less cell influx into the synovial layer and joint cavity 3 days after arthritis induction using immune complexes
• knee joint swelling is also reduced relative controls at both 1 and 3 days after induction
• less proteoglycan loss relative to controls at 1 and 3 days after induction
• chondrocyte death 3X the level in controls at 3 days after induction but normal at 1 day on the femoral surface
• chondrocyte cell death is unaffected on the patellar surface
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