Phenotypes Associated with This Genotype

Genotype
MGI:3052684

cn9

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem; Tg(Cyp1a1-cre)1Dwi/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:92092 )

• 4 days after BNF treatment increased apoptosis is seen in crypt epithelium

abnormal crypts of Lieberkuhn morphology ( J:92092 )

• 4 days after BNF treatment the number of crypts is reduced however by 5 days post treatment surviving crypts with unrecombined cells are enlarged and show increased proliferation

decreased Paneth cell number ( J:92092 )

• the number of Paneth cells is reduced within the crypt 4 days after BNF treatment

ectopic Paneth cells ( J:92092 )

• Paneth cells are in abnormal locations within the crypt 4 days after BNF treatment

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:92092 )

• 4 days after BNF treatment the number of crypts is reduced however by 5 days post treatment surviving crypts with unrecombined cells are enlarged and show increased proliferation

decreased Paneth cell number ( J:92092 )

• the number of Paneth cells is reduced within the crypt 4 days after BNF treatment

ectopic Paneth cells ( J:92092 )

• Paneth cells are in abnormal locations within the crypt 4 days after BNF treatment