Phenotypes Associated with This Genotype

Genotype
MGI:3052685

• Allelic Composition: Pdx1^tm1Cvw/Pdx1⁺; Pbx1^tm1Mlc/Pbx1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

disorganized pancreatic islets ( J:75811 )

• disrupted architecture, inappropriate cell types interspersed with beta cells

decreased insulin secretion ( J:75811 )

growth/size/body

weight loss ( J:75811 )

• 9-10 weeks

homeostasis/metabolism

decreased insulin secretion ( J:75811 )

hyperglycemia ( J:75811 )

• onset between 9-10 weeks, progresses to overt diabetes

impaired glucose tolerance ( J:75811 )

increased urine glucose level ( J:75811 )

increased insulin sensitivity ( J:75811 )

renal/urinary system

increased urine glucose level ( J:75811 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:75811