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Phenotypes Associated with This Genotype
Genotype
MGI:3052728
Allelic
Composition		 Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (61 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (61 available)
Shhtm1Amc mutation (1 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
failure of heart looping ( J:92058 )
• no heart looping but normal embryo turning

nervous system
abnormal neuron specification ( J:92058 )
• ventral midline of neural tube occupied by a reduced population of motor neuron progenitors

craniofacial
proboscis ( J:92058 )
• extreme proboscis-like nasal process

growth/size/body
proboscis ( J:92058 )
• extreme proboscis-like nasal process

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
holoprosencephaly 3 DOID:0110875 OMIM:142945
 J:92058

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory