Phenotypes Associated with This Genotype

Genotype
MGI:3053446

• Allelic Composition: Pafah1b1^tm1Awb/Pafah1b1⁺
• Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:59817 )

• impaired in Morris water task

limb grasping ( J:59817 )

• abnormal clasping of hind paws on tail and wire suspension tests

impaired coordination ( J:59817 )

• as observed in a rotarod test

nervous system

delayed brain development ( J:49531 )

• neuronal migration slow or delayed

enlarged brain ventricles ( J:49531 )

abnormal hippocampus morphology ( J:49531 )

• disorganized

abnormal stratification in cerebral cortex ( J:49531 )

abnormal olfactory bulb morphology ( J:49531 )

• disorganized

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lissencephaly		DOID:0050453	OMIM:PS607432	J:49531 , J:59817
Miller-Dieker lissencephaly syndrome		DOID:0060469	OMIM:247200	J:49531 , J:59817