Phenotypes Associated with This Genotype

Genotype
MGI:3053453

• Allelic Composition: Slit3^{Gt(OST106158)Lex}/Slit3^{Gt(OST106158)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

heart right ventricle hypertrophy ( J:86149 )

muscle

heart right ventricle hypertrophy ( J:86149 )

diaphragmatic hernia ( J:86149 )

• herniated diaphragm due to a defective central tendon that remained fused to the liver

renal/urinary system

abnormal kidney morphology ( J:86149 )

• various defects affecting some mice

renal hypoplasia ( J:86149 )

• varying degrees of kidney hypoplasia

absent kidney ( J:86149 )

• unilateral or bilateral kidney agenesis observed in some mice

growth/size/body

heart right ventricle hypertrophy ( J:86149 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital diaphragmatic hernia		DOID:3827	OMIM:142340 OMIM:222400 OMIM:610187	J:86149