Phenotypes Associated with This Genotype

Genotype
MGI:3053798

• Allelic Composition: Plscr3^tm1Sims/Plscr3^tm1Sims
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased white fat cell size ( J:92404 )

• increased size of adipocytes

abnormal abdominal fat pad morphology ( J:92404 )

• aberrant accumulation of abdominal fat by 2 months of age

growth/size/body

obese ( J:92404 )

• body weight elevated by 2 months

• mild obesity at 19 weeks

homeostasis/metabolism

increased circulating leptin level ( J:92404 )

• elevation in plasma leptin at 19 weeks

abnormal glucose homeostasis ( J:92404 )

hyperglycemia ( J:92404 )

• mild hyperglycemia by 2 months of age, persisting to at least 6 months

impaired glucose tolerance ( J:92404 )

• glucose intolerance by two months of age

insulin resistance ( J:92404 )

• insulin resistance by two months of age

• adipocytes exhibit defective response to exogenous insulin

decreased circulating adiponectin level ( J:92404 )

• low levels of plasma adiponectin, ~50% decrease at 8 and 19 weeks

abnormal lipid homeostasis ( J:92404 )

• dyslipidemia

• increase in size and number of lipid droplets in bone marrow derived granulocytes and macrophages

abnormal circulating cholesterol level ( J:92404 )

• greater than 2 fold increase in cholesterol associated with VLDL and LDL at 19 weeks, smaller increase in HDL

increased circulating free fatty acids level ( J:92404 )

• elevated plasma nonesterified fatty acid levels by 19 weeks

increased circulating triglyceride level ( J:92404 )

• at 19 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:92404