Phenotypes Associated with This Genotype

Genotype
MGI:3054643

• Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased B cell proliferation ( J:50688 )

• proliferative response of B cells to anti-IgM is greatly enhanced

enlarged spleen ( J:50688 )

• moderate splenomegaly

abnormal leukopoiesis ( J:50688 )

abnormal myelopoiesis ( J:50688 )

• myeloid lineages in the spleen are also increased

increased lymphocyte cell number ( J:50688 )

• lymphoid cells in the peritoneal cavity increased about 2 fold

increased B cell number ( J:50688 )

• increased numbers of B cells in the spleen

increased B-1 B cell number ( J:50688 )

• B1 cells in the peritoneal cavity are increased

abnormal immunoglobulin level ( J:50688 )

• increased T cell independent antigen responses

• T cell dependent antigen responses were normal

increased IgA level ( J:50688 )

increased IgG2b level ( J:50688 )

• IgG2b levels were increased

increased IgG3 level ( J:50688 )

• IgG3 levels were 3X normal

immune system

increased B cell proliferation ( J:50688 )

• proliferative response of B cells to anti-IgM is greatly enhanced

enlarged spleen ( J:50688 )

• moderate splenomegaly

abnormal leukopoiesis ( J:50688 )

abnormal myelopoiesis ( J:50688 )

• myeloid lineages in the spleen are also increased

increased lymphocyte cell number ( J:50688 )

• lymphoid cells in the peritoneal cavity increased about 2 fold

increased B cell number ( J:50688 )

• increased numbers of B cells in the spleen

increased B-1 B cell number ( J:50688 )

• B1 cells in the peritoneal cavity are increased

abnormal immunoglobulin level ( J:50688 )

• increased T cell independent antigen responses

• T cell dependent antigen responses were normal

increased IgA level ( J:50688 )

increased IgG2b level ( J:50688 )

• IgG2b levels were increased

increased IgG3 level ( J:50688 )

• IgG3 levels were 3X normal

growth/size/body

enlarged spleen ( J:50688 )

• moderate splenomegaly

cellular

increased B cell proliferation ( J:50688 )

• proliferative response of B cells to anti-IgM is greatly enhanced

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:50688