Phenotypes Associated with This Genotype

Genotype
MGI:3054644

• Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon
• Genetic Background: B6.129S2-Pdcd1^tm1Hon

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

autoimmune arthritis ( J:78802 )

• increased layers of synovial tissues in foot joints at 6 months of age

• arthritic lesions more pronounced at 14 months of age

glomerulonephritis ( J:78802 )

• mild proliferative glomerulonephritis at 6 months age

• less than 50% of glomeruli affected

• by 14 months, 50% of mice with a lupus-like glomerulonephritis

abnormal response to transplant ( J:119356 )

• only about 80% of mice show long term MHC class II mismatch allograft survival (Bm12 into B6) compared to about 100% survival in wild-type mice

• however, survival time of MHC class I mismatch allografts is the same as wild-type controls

renal/urinary system

glomerulonephritis ( J:78802 )

• mild proliferative glomerulonephritis at 6 months age

• less than 50% of glomeruli affected

• by 14 months, 50% of mice with a lupus-like glomerulonephritis

skeleton

autoimmune arthritis ( J:78802 )

• increased layers of synovial tissues in foot joints at 6 months of age

• arthritic lesions more pronounced at 14 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:78802