Phenotypes for Casp8 Tg(Alb1-cre)7Gsc MGI:3055104 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Casp8^tm1Wll/Casp8^tm1.1Yuan Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8^tm1.1Yuan mutation (0 available); any Casp8 mutation (45 available)
Casp8^tm1Wll mutation (0 available); any Casp8 mutation (45 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:92722 )

• unlike mice that do not carry Casp8^tm1.1Yuan, compound heterozygous mutants survive after injection with an anti-Fas Ab

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:92722 )

• unlike mice that do not carry Casp8^tm1.1Yuan, compound heterozygous mutants survive and do not display liver damage after injection with an anti-Fas Ab

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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