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Phenotypes Associated with This Genotype
Genotype
MGI:3055111
cn5
Allelic
Composition		 Casp8tm1Wll/Casp8tm1.1Yuan
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1.1Yuan mutation (0 available); any Casp8 mutation (45 available)
Casp8tm1Wll mutation (0 available); any Casp8 mutation (45 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal macrophage differentiation ( J:92722 )
• the number monocyte progenitors is not decreased; however, recombined progenitors can not differentiate into macrophages
• the ability of bone marrow progenitors to differentiate into granulocytes is not impaired

immune system
abnormal macrophage differentiation ( J:92722 )
• the number monocyte progenitors is not decreased; however, recombined progenitors can not differentiate into macrophages
• the ability of bone marrow progenitors to differentiate into granulocytes is not impaired

cellular
abnormal macrophage differentiation ( J:92722 )
• the number monocyte progenitors is not decreased; however, recombined progenitors can not differentiate into macrophages
• the ability of bone marrow progenitors to differentiate into granulocytes is not impaired

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory