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Phenotypes Associated with This Genotype
Genotype
MGI:3055390
hm1
Allelic
Composition		 Abcc4tm1Jsch/Abcc4tm1Jsch
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc4tm1Jsch mutation (0 available); any Abcc4 mutation (153 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood-brain barrier function ( J:92788 )
• whole brain concentrations of topotecan, an organic anion, are increased almost 6-fold as a result of decreased anion transporter activity
abnormal blood-cerebrospinal fluid barrier function ( J:92788 )
• cerebrospinal fluid concentrations of topotecan, an organic anion, are increased almost 10-fold as a result of decreased anion transporter activity

renal/urinary system
abnormal urine organic anion level ( J:92788 )
• plasma concentrations is increased and urinary concentration of totpotecan is decreased indicating decreased renal excretion

nervous system
abnormal blood-brain barrier function ( J:92788 )
• whole brain concentrations of topotecan, an organic anion, are increased almost 6-fold as a result of decreased anion transporter activity
abnormal blood-cerebrospinal fluid barrier function ( J:92788 )
• cerebrospinal fluid concentrations of topotecan, an organic anion, are increased almost 10-fold as a result of decreased anion transporter activity

homeostasis/metabolism
abnormal urine organic anion level ( J:92788 )
• plasma concentrations is increased and urinary concentration of totpotecan is decreased indicating decreased renal excretion

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory