Phenotypes Associated with This Genotype

Genotype
MGI:3055422

hm1

• Allelic Composition: Thrb^tm1Few/Thrb^tm1Few
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid gland physiology ( J:56668 )

• homozygotes exhibit impaired suppression of thyroid hormone in response to administration of exogenous triiodothyronine (T3)

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:56668 )

N • homozygotes do not show any hearing deficits at any of the frequencies tested

N • surprisingly, 8-week-old wild-type and mutant mice display overlapping auditory brainstem response thresholds, indicating normal cochlear function

homeostasis/metabolism

increased thyroxine level ( J:56668 )

• homozygotes display a 2- to 3-fold increase in basal T4 concentrations relative to wild-type

increased triiodothyronine level ( J:56668 )

• homozygotes exhibit a 40% increase in basal T3 concentrations relative to wild-type

increased circulating thyroid-stimulating hormone level ( J:56668 )

• homozygotes exhibit a 2.5-fold increase in TSH concentrations relative to wild-type