Phenotypes for Nbn Tg(Mx1-cre)1Cgn MGI:3510438 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nbn^tm1Md/Nbn^tm1Zqw Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbn^tm1Md mutation (0 available); any Nbn mutation (59 available)
Nbn^tm1Zqw mutation (0 available); any Nbn mutation (59 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosome breakage ( J:93598 )

• recombined lymphocytes show increased chromosomal instability and cells in which cre mediated excision occurred are preferentially lost from the bone marrow, thymus, and spleen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Nijmegen breakage syndrome		DOID:7400	OMIM:251260	J:93598

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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