Phenotypes Associated with This Genotype

Genotype
MGI:3510652

• Allelic Composition: Psen1^tm1Lpr/Psen1^tm1Lpr; Tg(Thy1-APP^SL)28Lpr/0
• Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:93770 )

• accelerated rate of A-beta deposition starting at 2.5 months of age

• by 6 months of age deposition has become widespread and numerous in cortical, hippocampal and thalamic areas

• astrocytic and microglial activation around amyloid plaques

abnormal hippocampus pyramidal cell layer ( J:93770 )

• marked reduction in thickness of the hippocampal pyramidal cell layer by 10 months of age

• no amyloid plaques in the CA1/2 pyramidal cell layer

homeostasis/metabolism

amyloid beta deposits ( J:93770 )

• accelerated rate of A-beta deposition starting at 2.5 months of age

• by 6 months of age deposition has become widespread and numerous in cortical, hippocampal and thalamic areas

• astrocytic and microglial activation around amyloid plaques

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:93770
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:93770