Phenotypes Associated with This Genotype

Genotype
MGI:3510669

• Allelic Composition: Irs2^tm2Mfw/Irs2^tm2Mfw; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:93415 )

• mutants closely resemble agouti mice or mice deficient in Pmoc1 or Mcr4

adipose tissue

increased total body fat amount ( J:93415 )

• body fat is increased 2-fold, a disproportionate increase relative to the increase in body weight

behavior/neurological

polydipsia ( J:93415 )

• mutants drink 65% more water than wild-type mice

polyphagia ( J:93415 )

• mutants consume 60% more food than wild-type mice

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:93415 )

• the number of beta cells does not increase from 4 to 8 weeks of age unlike in wild-type mice, however by 6 months beta cell numbers are normal as a result of proliferation of cells that escaped cre mediated recombination

growth/size/body

increased body weight ( J:93415 )

• increased body weight is seen after 4 weeks of age with mutants weighing 30% more than wild-type mice at 32 weeks of age

• lean mass and total body fat are increased relative to wild-type mice

increased body length ( J:93415 )

• mutants are 10% longer than wild-type mice

homeostasis/metabolism

increased circulating glucose level ( J:93415 )

• fasting and random-fed glucose levels are elevated

increased circulating insulin level ( J:93415 )

• serum insulin is increased 2-fold, however pancreatic insulin levels were decreased more than 2-fold

• increased circulating insulin levels are also seen on a low fat diet

increased circulating leptin level ( J:93415 )

• serum leptin is increased 2-fold

impaired glucose tolerance ( J:93415 )

• glucose intolerance is seen on a normal or low fat diet

insulin resistance ( J:93415 )

• glucose clearance rates were decreased about 50% indicating peripheral insulin resistance

integument

abnormal coat/hair pigmentation ( J:93415 )

• mutants closely resemble agouti mice or mice deficient in Pmoc1 or Mcr4

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:93415