Phenotypes for Irs1 Irs2 Tg(Ins2-cre)25Mgn MGI:3510670 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Irs1^tm1Jos/Irs1⁺ Irs2^tm2Mfw/Irs2^tm2Mfw Tg(Ins2-cre)25Mgn/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1^tm1Jos mutation (0 available); any Irs1 mutation (52 available)
Irs2^tm2Mfw mutation (0 available); any Irs2 mutation (37 available)
Tg(Ins2-cre)25Mgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:93415 )

• at 6 months beta cell content is decreased 8-fold

growth/size/body

decreased body weight ( J:93415 )

homeostasis/metabolism

hyperglycemia ( J:93415 )

• diabetes and progressive severe hyperglycemia are seen starting at 4 weeks of age

decreased circulating insulin level ( J:93415 )

• severe, progressive hypoinsulinemia is seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:93415

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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