Phenotypes Associated with This Genotype

Genotype
MGI:3510920

• Allelic Composition: Tg(ALB-cre,CMV-rtTA)#Wcyy/0; Tg(CMV-EGFP,Rnu6-siAbca1)#Wcyy/0
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:93624 )

• serum cholesterol is reduced 35-40% 5 days after doxycycline treatment compared to untreated controls

liver/biliary system

hepatic steatosis ( J:93624 )

• lipid accumulation is seen only in the liver after doxycycline treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Tangier disease		DOID:1388	OMIM:205400	J:93624