Analysis Tools
mortality/aging
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• no homozygotes survive to weaning
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• 95% of mutants die within 1 day of birth
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craniofacial
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• failure of the palatal bones to extend across the roof of the oronasal cavity
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• by E15.5, the palatal shelves were hypoplastic and failed to fuse
• the number of medial edge epithelial cells is reduced and those present lack filopodia probably contributing to the failure of mutant palatal shelves to fuse even when brought into close contact in vitro
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• mutants that die shortly after birth have a complete cleft of the secondary palate
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• at E14.5, the palatal shelves failed to elevate, even when the tongue had moved away
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• the nasal septum is shorter than normal
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homeostasis/metabolism
respiratory system
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• the nasal septum is shorter than normal
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digestive/alimentary system
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• failure of the palatal bones to extend across the roof of the oronasal cavity
|
|
• by E15.5, the palatal shelves were hypoplastic and failed to fuse
• the number of medial edge epithelial cells is reduced and those present lack filopodia probably contributing to the failure of mutant palatal shelves to fuse even when brought into close contact in vitro
|
|
• mutants that die shortly after birth have a complete cleft of the secondary palate
|
|
• at E14.5, the palatal shelves failed to elevate, even when the tongue had moved away
|
embryo
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• develops in the lower spine and is evident at birth
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nervous system
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• develops in the lower spine and is evident at birth
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skeleton
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• failure of the palatal bones to extend across the roof of the oronasal cavity
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• develops in the lower spine and is evident at birth
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integument
blistering
(
J:93954
)
|
• severe blistering, often filled with blood, is seen in the frontonasal and lateral forehead region
• subepithelial blistering is seen in the posterior portion of the secondary palate and nasal septum
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growth/size/body
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• failure of the palatal bones to extend across the roof of the oronasal cavity
|
|
• by E15.5, the palatal shelves were hypoplastic and failed to fuse
• the number of medial edge epithelial cells is reduced and those present lack filopodia probably contributing to the failure of mutant palatal shelves to fuse even when brought into close contact in vitro
|
|
• mutants that die shortly after birth have a complete cleft of the secondary palate
|
|
• at E14.5, the palatal shelves failed to elevate, even when the tongue had moved away
|
|
• the nasal septum is shorter than normal
|
