Phenotypes Associated with This Genotype

Genotype
MGI:3511174

cn2

• Allelic Composition: Traf3ip2^tm1Lix/Traf3ip2^tm1.1Lix; Tg(CD19-cre/ERT2)1Cgn/0
• Genetic Background: involves: 129/Sv * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:93923 )

• this is less severe than in Act1 null mice

increased dendritic cell number ( J:93923 )

• the number of dendritic cells is increased in the spleen, this is less severe than in Act1 null mice

increased B cell number ( J:93923 )

• the total splenic B cell population is increased however the proportions of different B cell stages are the same as in wild-type littermates

• this is less severe than in Act1 null mice

increased immunoglobulin level ( J:93923 )

• this is less severe than in Act1 null mice

immune system

enlarged spleen ( J:93923 )

• this is less severe than in Act1 null mice

increased dendritic cell number ( J:93923 )

• the number of dendritic cells is increased in the spleen, this is less severe than in Act1 null mice

increased B cell number ( J:93923 )

• the total splenic B cell population is increased however the proportions of different B cell stages are the same as in wild-type littermates

• this is less severe than in Act1 null mice

increased immunoglobulin level ( J:93923 )

• this is less severe than in Act1 null mice

enlarged lymph nodes ( J:93923 )

• this is less severe than in Act1 null mice

growth/size/body

enlarged spleen ( J:93923 )

• this is less severe than in Act1 null mice