Phenotypes Associated with This Genotype

Genotype
MGI:3511746

• Allelic Composition: Lepr^tm1Chua/Lepr^tm1Chua
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Obesity in Lepr^tm1Chua/Lepr^tm1Chua mice (center) and normal weight in Lepr^tm1.1Chua/Lepr^tm1.1Chua (left)

behavior/neurological

polyphagia ( J:94019 )

• males hyperphagic, consume 66.4% more food in a given period

growth/size/body

obese ( J:94019 )

• visibly obese at weaning

increased susceptibility to weight gain ( J:94019 )

• at 16 weeks of age, males are 91% heavier than normal and females are 140% heavier

homeostasis/metabolism

impaired adaptive thermogenesis ( J:94019 )

• males are cold intolerant, suffer severe drops in body temperature when exposed to 0C for up to 80 minutes

increased circulating leptin level ( J:94019 )

abnormal glucose homeostasis ( J:94019 )

increased circulating glucose level ( J:94019 )

• increased serum glucose, by 144% in males and by 75% in females

increased circulating insulin level ( J:94019 )

reproductive system

infertility ( J:94019 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:94019