Phenotypes Associated with This Genotype

Genotype
MGI:3511748

• Allelic Composition: Lepr^tm1.2Chua/Lepr^tm1.2Chua
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Obesity in Lepr^tm1.2Chua/Lepr^tm1.2Chua mice

behavior/neurological

polyphagia ( J:94019 )

• males hyperphagic, consume 34.8% more food in a given period

growth/size/body

obese ( J:94019 )

increased susceptibility to weight gain ( J:94019 )

• males are 58.6% heavier than normal and females are 140.1% heavier

homeostasis/metabolism

impaired adaptive thermogenesis ( J:94019 )

• males are cold intolerant

abnormal glucose homeostasis ( J:94019 )

hyperglycemia ( J:94019 )

• males were severely hyperglycemic

increased circulating insulin level ( J:94019 )

• insulin concentration about 2.6X normal

reproductive system

infertility ( J:94019 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:94019