Phenotypes Associated with This Genotype

Genotype
MGI:3512777

hm1

• Allelic Composition: Psmb9^tm1Stl/Psmb9^tm1Stl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:73945 )

• low incidence of spontaneous hepatocellular carcinomas in both sexes

increased leiomyosarcoma incidence ( J:73945 )

• prone to uterine neoplasms

• the number of animals developing overt tumors increases after 6 months of age, mostly leiomyosarcomas

increased lung tumor incidence ( J:73945 )

• low incidence of severe lung tumors seen in both sexes

liver/biliary system

increased hepatocellular carcinoma incidence ( J:73945 )

• low incidence of spontaneous hepatocellular carcinomas in both sexes

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:21549 )

• by 36% in blood

• by 22% in spleen

• by 49% in thymus

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:21549 )

• 5-6 fold lower levels of cytotoxic T lymphocyte precursors after infection with influenza A virus but not Sendai virus

muscle

increased leiomyosarcoma incidence ( J:73945 )

• prone to uterine neoplasms

• the number of animals developing overt tumors increases after 6 months of age, mostly leiomyosarcomas

immune system

decreased CD8-positive, alpha-beta T cell number ( J:21549 )

• by 36% in blood

• by 22% in spleen

• by 49% in thymus

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:21549 )

• 5-6 fold lower levels of cytotoxic T lymphocyte precursors after infection with influenza A virus but not Sendai virus

abnormal immune system physiology ( J:21549 )

• splenic lymphoblasts and peritoneal exudates cells are less efficient stimulators of CD8+ T cells

increased susceptibility to Orthomyxoviridae infection ( J:21549 )

• 5-6 fold lower levels of cytotoxic T lymphocyte precursors after infection with influenza A virus but not Sendai virus

respiratory system

increased lung tumor incidence ( J:73945 )

• low incidence of severe lung tumors seen in both sexes