Phenotypes for Psmb9 Trp53 MGI:3512781 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Psmb9^tm1Stl/Psmb9^tm1Stl Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb9^tm1Stl mutation (2 available); any Psmb9 mutation (24 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (244 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:67509 )

• 89% of mice develop tumors

• somewhat decreased survival compared to singly homozygous Trp53^tm1Brd

increased lymphoma incidence ( J:67509 )

• mostly

increased sarcoma incidence ( J:67509 )

• with lesser frequency than lymphomas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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