Phenotypes Associated with This Genotype

Genotype
MGI:3512883

• Allelic Composition: Wt1^tm1Vih/Wt1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:94225 )

• several mice died at 4 to 5 months of age

homeostasis/metabolism

increased urine protein level ( J:94225 )

• 100% of males and 43% of females at 4 months of age and 71% of females at 10 to 12 months of age displayed proteinuria

renal/urinary system

increased urine protein level ( J:94225 )

• 100% of males and 43% of females at 4 months of age and 71% of females at 10 to 12 months of age displayed proteinuria

podocyte foot process effacement ( J:94225 )

• effacement of podocyte foot processes

glomerulosclerosis ( J:94225 )

• 33% of males and 0% of females by 2 months of age and 100% of males and 43% of females at 4 months of age displayed glomerulosclerosis

• medullary regions of the kidneys had dilated tubules and protein casts, a few glomeruli with segmental sclerosis, and predominately glomeruli with global mesangial sclerosis

• glomeruli displayed severe thickening of the glomerular basement membrane

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Denys-Drash syndrome		DOID:3764	OMIM:194080	J:94225