Phenotypes Associated with This Genotype

Genotype
MGI:3513188

• Allelic Composition: Hoxd13^tm1Mrc/Hoxd13^tm1Mrc
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

absent carpal bone ( J:32603 )

• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI

brachyphalangia ( J:32603 )

• homozygotes show a reduction or loss of phalange 2 on digits II and V

• phalangeal bones on other digits are also reduced due to abnormal segmentation

polydactyly ( J:32603 )

• homozygotes display the formation of an extra postaxial digit ("VI")

interdigital webbing ( J:32603 )

• interdigital webbing is sometimes observed

short metacarpal bones ( J:32603 )

• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length

skeleton

absent carpal bone ( J:32603 )

• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI

brachyphalangia ( J:32603 )

• homozygotes show a reduction or loss of phalange 2 on digits II and V

• phalangeal bones on other digits are also reduced due to abnormal segmentation

short metacarpal bones ( J:32603 )

• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:82540 )

N • ventral prostate appears normal with no reductions in duct tip numbers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
synpolydactyly		DOID:0060242	OMIM:186000 OMIM:608180 OMIM:610234	J:32603