Phenotypes for Prop1 MGI:3521856 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Prop1^df/Prop1^df
Genetic Background	involves: C57BL/6J

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prop1^df mutation (2 available); any Prop1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:94409 )

• a fraction of pups with a higher contribution of the C57BL/6J background display lethargy and die precipitously between weaning and adulthood

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:94409 )

N	• mutants crossed onto the C57BL/6J background have normal levels of gonadotropes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypopituitarism		DOID:9406		J:94409

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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