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Phenotypes Associated with This Genotype
Genotype
MGI:3521968
Allelic
Composition		 Cnga3tm1Biel/Cnga3tm1Biel
Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga3tm1Biel mutation (0 available); any Cnga3 mutation (27 available)
Rpe65tm1Tmr mutation (1 available); any Rpe65 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye electrophysiology ( J:71529 )
• at stimuli ranging from 0.0001 to 25 cds/m2, scotopic single-flash ERGs of double homozygotes are almost identical to those of Rpe65tm1Tmr single mutants, indicating that rods are responsible for the light responses in Rpe65tm1Tmr mutants

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Leber congenital amaurosis 2 DOID:0110016 OMIM:204100
 J:71529

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory