Phenotypes Associated with This Genotype

Genotype
MGI:3522483

• Allelic Composition: Lama2^tm1Eeng/Lama2^tm1Eeng
• Genetic Background: involves: 129S1/Sv * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

dystrophic muscle ( J:59089 )

• 1 month old skeletal muscle showed fiber necrosis and fibrosis, indicating muscle degeneration and developed muscular dystrophy at 2-3 weeks of age

impaired skeletal muscle regeneration ( J:59089 )

• skeletal muscle was unable to complete regeneration in response to injury

• low incidence of new myotube formation

• newly formed myofibers undergo apoptosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital merosin-deficient muscular dystrophy 1A		DOID:0110636	OMIM:607855	J:59089