Phenotypes Associated with This Genotype

Genotype
MGI:3522485

• Allelic Composition: Lama2^tm1Eeng/Lama2^tm1Eeng
• Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:49435 )

• most die within 2-4 weeks after birth though a few survive up to 3-4 months

postnatal lethality, incomplete penetrance ( J:49435 )

• most die within 2-4 weeks after birth though a few survive up to 3-4 months

behavior/neurological

decreased aggression ( J:49435 )

• homozygotes were passive

limb grasping ( J:49435 )

• from 2-3 weeks of age, flexed hind legs to the trunk when lifted by the tail

hindlimb paralysis ( J:49435 )

• hindlimbs become increasingly paralyzed with age

growth/size/body

decreased body size ( J:49435 )

• 1 and 3 month old mutants are smaller and thinner than wild-type

decreased body weight ( J:49435 )

muscle

dystrophic muscle ( J:49435 )

• showed extensive muscle degeneration, muscle fiber necrosis and pronounced fibrosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital merosin-deficient muscular dystrophy 1A		DOID:0110636	OMIM:607855	J:49435