Phenotypes Associated with This Genotype

Genotype
MGI:3522660

• Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:89472 )

• after diethylnitrosamine (DEN) and phenobarbitol (PB) treatment, multiple hepatic adenomas were observed in liver sections from these mice at 23, 33 and 50 weeks of age

increased hepatocellular carcinoma incidence ( J:89472 )

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:89472 )

• after diethylnitrosamine (DEN) and phenobarbitol (PB) treatment, multiple hepatic adenomas were observed in liver sections from these mice at 23, 33 and 50 weeks of age

liver/biliary system

increased hepatocellular carcinoma incidence ( J:89472 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:89472