Phenotypes Associated with This Genotype

Genotype
MGI:3525013

• Allelic Composition: Nppa^tm1Unc/Nppa⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

heart right ventricle hypertrophy ( J:64898 )

• after a 5-wk hypoxic exposure (10% O2), hypoxia-induced increases in RV mass are significantly higher in heterozygous than in wild-type (294% vs. 265%, respectively)

abnormal heart right ventricle pressure ( J:64898 )

• after a 5-wk hypoxic exposure (10% O2), hypoxia-induced increases in right ventricular (RV) pressure are significantly higher in heterozygous than in wild-type mice (637% vs. 4510%, respectively)

salt-sensitive hypertension ( J:76312 )

• when fed on standard chow (0.8% NaCl) for 2 weeks, heterozygotes display normal blood pressures and normal heart rates relative to wild-type

• when fed on high salt chow (8% NaCl) for 2 weeks, heterozygotes become hypertensive, with blood pressures elevated by 27 mm Hg relative to wild-type; heart rates remain unaffected relative to wild-type

muscle

heart right ventricle hypertrophy ( J:64898 )

• after a 5-wk hypoxic exposure (10% O2), hypoxia-induced increases in RV mass are significantly higher in heterozygous than in wild-type (294% vs. 265%, respectively)

growth/size/body

heart right ventricle hypertrophy ( J:64898 )

• after a 5-wk hypoxic exposure (10% O2), hypoxia-induced increases in RV mass are significantly higher in heterozygous than in wild-type (294% vs. 265%, respectively)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertension		DOID:10763		J:76312