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Phenotypes Associated with This Genotype
Genotype
MGI:3525013
Allelic
Composition
Nppatm1Unc/Nppa+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nppatm1Unc mutation (1 available); any Nppa mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after a 5-wk hypoxic exposure (10% O2), hypoxia-induced increases in RV mass are significantly higher in heterozygous than in wild-type (294% vs. 265%, respectively)
• after a 5-wk hypoxic exposure (10% O2), hypoxia-induced increases in right ventricular (RV) pressure are significantly higher in heterozygous than in wild-type mice (637% vs. 4510%, respectively)
• when fed on standard chow (0.8% NaCl) for 2 weeks, heterozygotes display normal blood pressures and normal heart rates relative to wild-type
• when fed on high salt chow (8% NaCl) for 2 weeks, heterozygotes become hypertensive, with blood pressures elevated by 27 mm Hg relative to wild-type; heart rates remain unaffected relative to wild-type

muscle
• after a 5-wk hypoxic exposure (10% O2), hypoxia-induced increases in RV mass are significantly higher in heterozygous than in wild-type (294% vs. 265%, respectively)

growth/size/body
• after a 5-wk hypoxic exposure (10% O2), hypoxia-induced increases in RV mass are significantly higher in heterozygous than in wild-type (294% vs. 265%, respectively)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertension DOID:10763 J:76312


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory