Phenotypes Associated with This Genotype

Genotype
MGI:3525159

• Allelic Composition: Nfatc2^tm1Glm/Nfatc2^tm1Glm; Nfatc3^tm1Glm/Nfatc3^tm1Glm; Nfatc4^tm1Grc/Nfatc4^tm1Grc
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

decreased embryo size ( J:83744 )

• smaller than stage matched controls

• stages were not delayed

growth/size/body

decreased embryo size ( J:83744 )

• smaller than stage matched controls

• stages were not delayed

nervous system

abnormal sensory neuron innervation pattern ( J:83744 )

• defects in sensory axon projections found in 100% of triple mutants

• spinal sensory neurons failed to project longitudinally

• commissural axon growth is disrupted

abnormal trigeminal nerve morphology ( J:83744 )

• trigeminal axons stunted at E10.5

abnormal spinal cord dorsal column morphology ( J:83744 )

• dorsal funiculus absent or fragmented

behavior/neurological

decreased anxiety-related response ( J:109139 )

decreased grip strength ( J:109139 )

• mutants display decreased grip strength compared to controls

abnormal locomotor activation ( J:109139 )

• mice show increased locomotor activity compared to BALB/c controls

abnormal social/conspecific interaction behavior ( J:109139 )

• mutants show increased social interaction

muscle

hypotonia ( J:109139 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:109139